Cliostomum leprosum is a crustose lichen-forming fungus in the family Ramalinaceae, notable for its powdery, leprose thallus that gives it a granular, mealy appearance on bark and wood substrates. Unlike many lichens that form well-defined, structured thalli, C. leprosum produces a loosely coherent sorediose crust ranging from pale greenish-grey to whitish, often colonizing deeply shaded, moist bark on deciduous and coniferous trees. The species is distributed across boreal and temperate forests of Europe and North America, with confirmed records from Norway, Sweden, and scattered locations in the United States. It photosynthesizes in partnership with green algal partners typical of crustose lichens. Cliostomum leprosum is assessed as Vulnerable due to its sensitivity to air pollution, particularly sulfur dioxide and nitrogen compounds that degrade lichen communities. Its decline is linked to habitat loss from intensive forestry, removal of veteran trees, and acidic deposition. Conservation efforts focus on preserving old-growth and semi-natural forest stands that provide suitable, low-disturbance bark microhabitats where this inconspicuous but ecologically significant lichen can persist.