Discovery of Hox Genes

Evolution & Adaptation 1984 Featured

Discoverers: Edward B. Lewis, Christiane Nüsslein-Volhard, Eric Wieschaus

Overview

Identification of homeotic selector genes (Hox genes) that control body plan development across virtually all animal phyla.

Significance

Revealed that a shared genetic toolkit underlies the stunning diversity of animal body forms, connecting developmental biology to evolutionary theory.

Methodology

Systematic genetic screens in Drosophila melanogaster identifying mutations that transform one body segment into another.

Impact