Discovery of Transposons

Genetics & Genomics 1948 Featured

Discoverers: Barbara McClintock

Overview

Identification of mobile genetic elements (transposons or 'jumping genes') in maize, showing that segments of DNA can change position within the genome.

Significance

Overturned the static view of chromosomes and revealed a dynamic genome capable of self-reorganisation, influencing evolution and gene regulation.

Methodology

Cytogenetic analysis of colour patterns in maize kernels combined with chromosome breakage-fusion-bridge cycle studies.

Impact