vs

Clostridium botulinum compared with Clostridium tertium

Taxonomic Classification

Rank
Kingdom same	Bacteria (Bacteria)	Bacteria (Bacteria)
Phylum same	Firmicutes_A	Firmicutes_A
Class same	Clostridia (Clostridia)	Clostridia (Clostridia)
Order same	Clostridiales (Clostridiales)	Clostridiales (Clostridiales)
Family same	Clostridiaceae	Clostridiaceae
Genus same	Clostridium	Clostridium
Species	Clostridium botulinum	Clostridium tertium

Evolutionary Relationship

and share a common ancestor at the Genus level: Clostridium.

Conservation Status

NE — Not Evaluated

NE — Not Evaluated

Physical Characteristics

Attribute
Diet	—	—
Average Lifespan	—	—
Average Length	—	—
Average Weight	—	—

Habitat & Geographic Range

Habitat

Native to Europe, inhabiting ecosystems characteristic of the region.

Range

Found in Sweden.

Habitat

Native to Asia, inhabiting ecosystems characteristic of the region.

Range

Found in Taiwan.

Clostridium botulinum is an anaerobic, endospore-forming bacterium in the family Clostridiaceae and the causative agent of botulism, a potentially fatal neuroparalytic illness caused by its potent botulinum neurotoxin — the most acutely toxic substance known. The neurotoxin acts by blocking acetylcholine release at neuromuscular junctions, causing flaccid paralysis and potentially respiratory failure. Seven serologically distinct toxin types (A through G) are produced by different strains, with types A, B, E, and F responsible for human botulism occurring through foodborne intoxication, wound infection, and infant intestinal colonization. C. botulinum spores are ubiquitous in soil and sediments worldwide, resisting boiling for extended periods and requiring autoclaving to destroy. Home-canned low-acid foods provide ideal anaerobic, low-acid conditions for germination and toxin production. Paradoxically, purified botulinum toxin has extensive medical applications, used clinically to treat spasticity, hyperhidrosis, chronic migraine, and cosmetically to reduce facial wrinkles (Botox). Strains are distributed globally and isolated from soils, sediments, and animal intestines across all continents.

Clostridium tertium is an aerotolerant, endospore-forming bacterium in the family Clostridiaceae notable among clostridia for its ability to grow in the presence of atmospheric oxygen, despite being classified within the genus of strictly anaerobic organisms. Its relative aerotolerance distinguishes it from most genus members and contributes to its occasional isolation from clinical sources. C. tertium is considered an opportunistic pathogen, causing bacteremia primarily in immunocompromised patients including those undergoing chemotherapy, with neutropenia as a key risk factor. The bacterium has been isolated from soil, water, and the gastrointestinal tract of animals and humans. Despite causing bacteremia and occasionally more invasive infections, C. tertium does not produce recognized exotoxins comparable to the major histotoxic clostridia, and its pathogenic mechanisms involve host immune evasion rather than direct toxin-mediated tissue destruction. Clinically, C. tertium bacteremia carries significant mortality in neutropenic patients but responds to beta-lactam antibiotics unlike C. difficile or C. perfringens infections. Its natural aerotolerance makes it unusual within the Clostridium genus and raises evolutionary questions about the anaerobic ancestry of this lineage.